Reactome | ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE

ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE

Stable Identifier

R-HSA-9018863

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE

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Unlike resolvin E3, which is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway, resolvins E1 and E2 are biosynthesised by neutrophils via the 5-lipoxygenase pathway. In neutrophils, ALOX5 oxidises 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) to 5(R)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(R)-Hp-18(R)-HEPE) (Tjonahen et al. 2006, Oh et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22450811	Resolvin E2 formation and impact in inflammation resolution Oh, SF, Dona, M, Fredman, G, Krishnamoorthy, S, Irimia, D, Serhan, CN	J. Immunol.	2012
17114001	Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis Tjonahen, E, Oh, SF, Siegelman, J, Elangovan, S, Percarpio, KB, Hong, S, Arita, M, Serhan, CN	Chem. Biol.	2006