Unlike resolvin E3, which is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway, resolvins E1 and E2 are biosynthesised by neutrophils via the 5-lipoxygenase pathway. In neutrophils, ALOX5 oxidises 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) to 5(R)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(R)-Hp-18(R)-HEPE) (Tjonahen et al. 2006, Oh et al. 2012).
Serhan, CN, Arita, M, Percarpio, KB, Oh, SF, Elangovan, S, Hong, S, Tjonahen, E, Siegelman, J
Serhan, CN, Dona, M, Krishnamoorthy, S, Irimia, D, Oh, SF, Fredman, G
arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]
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