Reactome | ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE

ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE

Stable Identifier

R-HSA-9018863

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate

ReviewStatus

5/5

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ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE

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Unlike resolvin E3, which is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway, resolvins E1 and E2 are biosynthesised by neutrophils via the 5-lipoxygenase pathway. In neutrophils, ALOX5 oxidises 18(R)-hydroxyeicosapentaenoic acid (18(R)-HEPE) to 5(R)-hydroperoxy-18(R)-hydroxyeicosapentaenoic acid (5(R)-Hp-18(R)-HEPE) (Tjonahen et al. 2006, Oh et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
17114001	Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis Serhan, CN, Arita, M, Percarpio, KB, Oh, SF, Elangovan, S, Hong, S, Tjonahen, E, Siegelman, J	Chem. Biol.	2006
22450811	Resolvin E2 formation and impact in inflammation resolution Serhan, CN, Dona, M, Krishnamoorthy, S, Irimia, D, Oh, SF, Fredman, G	J. Immunol.	2012