Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 5S,6S-epoxy-18(S)-HEPE to the 18(S) stereoisomer of resolvin E1 (18(S)-RvE1) (Oh et al. 2011). The E-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Pillai, PS, Serhan, CN, Oh, SF, Yang, R, Recchiuti, A
epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
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