RHOT2 binds effectors at the mitochondrial outer membrane

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
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Active GTP-bound RHOT2 interacts with the following effectors:
MFN1 (Nemani et al. 2018)
MFN2 (Nemani et al. 2018)
MYO19 (Oeding et al. 2018; Bocanegra et al. 2020)
TRAK1 (Fransson et al. 2006)
TRAK2 (Fransson et al. 2006)

Literature References
PubMed ID Title Journal Year
16630562 The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking

Ruusala, A, Aspenström, P, Fransson, S

Biochem. Biophys. Res. Commun. 2006
29694881 MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress

Caplan, J, Sesaki, H, Shanmughapriya, S, Jaña, F, Breves, SL, Craigen, WJ, Chan, DC, Rajan, S, Tomar, D, Manfred, T, Mishra, P, Riitano, MF, Itoh, K, Palaniappan, P, Tripathi, A, Carvalho, E, Madesh, M, Worth, AM, Subbiah, R, Meng, S, Gill, DL, Ketschek, A, Seelam, A, Heffler, J, Prosser, BL, Dong, Z, Nemani, N, Gallo, G, Stathopulos, PB

Cell Rep 2018
30111583 Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX

Schwarz, V, Honnert, U, Freitag, A, Majstrowicz, K, Oeding, SJ, Bähler, M, Nikolaus, P, Hu, XP

J. Cell. Sci. 2018
31479585 The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes

Major, MB, Melton, NR, Schinski, EL, Cowan, JM, Tamir, TY, Bocanegra, JL, Quintero, OA, Fujita, BM

Cytoskeleton (Hoboken) 2020
Orthologous Events
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