Reactome | RHOT2 binds effectors at the mitochondrial outer membrane

RHOT2 binds effectors at the mitochondrial outer membrane

Stable Identifier

R-HSA-9018824

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

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RHOT2 binds effectors at the mitochondrial outer membrane

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Active GTP-bound RHOT2 interacts with the following effectors:
MFN1 (Nemani et al. 2018)
MFN2 (Nemani et al. 2018)
MYO19 (Oeding et al. 2018; Bocanegra et al. 2020)
TRAK1 (Fransson et al. 2006)
TRAK2 (Fransson et al. 2006)

Literature References

PubMed ID	Title	Journal	Year
16630562	The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking Ruusala, A, Aspenström, P, Fransson, S	Biochem. Biophys. Res. Commun.	2006
29694881	MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca²⁺ Stress Caplan, J, Sesaki, H, Shanmughapriya, S, Jaña, F, Breves, SL, Craigen, WJ, Chan, DC, Rajan, S, Tomar, D, Manfred, T, Mishra, P, Riitano, MF, Itoh, K, Palaniappan, P, Tripathi, A, Carvalho, E, Madesh, M, Worth, AM, Subbiah, R, Meng, S, Gill, DL, Ketschek, A, Seelam, A, Heffler, J, Prosser, BL, Dong, Z, Nemani, N, Gallo, G, Stathopulos, PB	Cell Rep	2018
30111583	Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX Schwarz, V, Honnert, U, Freitag, A, Majstrowicz, K, Oeding, SJ, Bähler, M, Nikolaus, P, Hu, XP	J. Cell. Sci.	2018
31479585	The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes Major, MB, Melton, NR, Schinski, EL, Cowan, JM, Tamir, TY, Bocanegra, JL, Quintero, OA, Fujita, BM	Cytoskeleton (Hoboken)	2020