RAC3 GDIs block activation of RAC3

Stable Identifier
R-HSA-9018807
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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RAC3 GDIs block activation of RAC3
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ARHGDIB, a GDP dissociation inhibitor (GDI), binds to RAC3 (Zhang et al. 2009) and is a candidate RAC3 inhibitor.

Literature References
PubMed ID Title Journal Year
19269969 Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling

Rivera Rosado, LA, Zhang, Y, Zhang, B, Moon, SY

J. Biol. Chem. 2009
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Orthologous Events
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RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)
RAC3 GDIs block activation of RAC3 (Drosophila melanogaster)
RAC3 GDIs block activation of RAC3 (Gallus gallus)
RAC3 GDIs block activation of RAC3 (Mus musculus)
RAC3 GDIs block activation of RAC3 (Rattus norvegicus)
RAC3 GDIs block activation of RAC3 (Saccharomyces cerevisiae)
RAC3 GDIs block activation of RAC3 (Sus scrofa)
RAC3 GDIs block activation of RAC3 (Xenopus tropicalis)
Authored
Rothfels, K  (2020-07-14)
Orlic-Milacic, M  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Created
Orlic-Milacic, M  (2017-09-05)
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