Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RAC3 GDIs block activation of RAC3
Stable Identifier
R-HSA-9018807
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GDIs block activation of RAC3 (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ARHGDIB, a GDP dissociation inhibitor (GDI), binds to RAC3 (Zhang et al. 2009) and is a candidate RAC3 inhibitor.
Literature References
PubMed ID
Title
Journal
Year
19269969
Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling
Rivera Rosado, LA
,
Zhang, Y
,
Zhang, B
,
Moon, SY
J. Biol. Chem.
2009
Participants
Input
RAC3 GDIs [cytosol]
(Homo sapiens)
RAC3:GDP [plasma membrane]
(Homo sapiens)
Output
RAC3:GDP:RAC3 GDIs [cytosol]
(Homo sapiens)
Participates
as an event of
RAC3 GTPase cycle (Homo sapiens)
Orthologous Events
RAC3 GDIs block activation of RAC3 (Bos taurus)
RAC3 GDIs block activation of RAC3 (Caenorhabditis elegans)
RAC3 GDIs block activation of RAC3 (Canis familiaris)
RAC3 GDIs block activation of RAC3 (Danio rerio)
RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)
RAC3 GDIs block activation of RAC3 (Drosophila melanogaster)
RAC3 GDIs block activation of RAC3 (Gallus gallus)
RAC3 GDIs block activation of RAC3 (Mus musculus)
RAC3 GDIs block activation of RAC3 (Sus scrofa)
RAC3 GDIs block activation of RAC3 (Xenopus tropicalis)
Authored
Rothfels, K (2020-07-14)
Orlic-Milacic, M (2020-07-14)
Reviewed
Fort, P (2021-02-05)
Created
Orlic-Milacic, M (2017-09-05)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text