Reactome | RAC3 GEFs activate RAC3

RAC3 GEFs activate RAC3

Stable Identifier

R-HSA-9018804

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC3 and catalyze GDP to GTP exchange on RAC3, resulting in formation of the active RAC3:GTP complex:
MCF2 (Jaiswal et al. 2013)
PREX1 (Waters et al. 2008; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003)
TRIO (Jaiswal et al. 2013)
VAV2 (Rosenberg et al. 2017; Jaiswal et al. 2013)

DOCK10 is annotated as a candidate RAC3 GEF, because it binds to RAC3 but its ability to activate RAC3 is uncertain (Ruiz-Lafuente et al. 2015).

The following GEFs do not act on RAC3:
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)

Literature References

PubMed ID	Title	Journal	Year
23255595	Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins Jaiswal, M, Dvorsky, R, Ahmadian, MR	J. Biol. Chem.	2013
18697831	P-Rex1 - a multidomain protein that regulates neurite differentiation Waters, JE, Astle, MV, Ooms, LM, Balamatsias, D, Gurung, R, Mitchell, CA	J. Cell. Sci.	2008
25862245	Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells Ruiz-Lafuente, N, Alcaraz-García, MJ, García-Serna, AM, Sebastián-Ruiz, S, Moya-Quiles, MR, García-Alonso, AM, Parrado, A	Biol Open	2015
14675773	Comparative functional analysis of the Rac GTPases Haeusler, LC, Blumenstein, L, Stege, P, Dvorsky, R, Ahmadian, MR	FEBS Lett.	2003
11704860	The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3 De Toledo, M, Coulon, V, Schmidt, S, Fort, P, Blangy, A	Oncogene	2001
28356423	Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells Rosenberg, BJ, Gil-Henn, H, Mader, CC, Halo, T, Yin, T, Condeelis, J, Machida, K, Wu, YI, Koleske, AJ	Mol. Biol. Cell	2017