RAC3 GEFs activate RAC3

Stable Identifier
Reaction [transition]
Homo sapiens
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The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC3 and catalyze GDP to GTP exchange on RAC3, resulting in formation of the active RAC3:GTP complex:
MCF2 (Jaiswal et al. 2013)
PREX1 (Waters et al. 2008; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003)
TRIO (Jaiswal et al. 2013)
VAV2 (Rosenberg et al. 2017; Jaiswal et al. 2013)

DOCK10 is annotated as a candidate RAC3 GEF, because it binds to RAC3 but its ability to activate RAC3 is uncertain (Ruiz-Lafuente et al. 2015).

The following GEFs do not act on RAC3:
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)

Literature References
PubMed ID Title Journal Year
18697831 P-Rex1 - a multidomain protein that regulates neurite differentiation

Waters, JE, Astle, MV, Ooms, LM, Balamatsias, D, Gurung, R, Mitchell, CA

J. Cell. Sci. 2008
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Jaiswal, M, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2013
25862245 Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells

Ruiz-Lafuente, N, Alcaraz-García, MJ, García-Serna, AM, Sebastián-Ruiz, S, Moya-Quiles, MR, García-Alonso, AM, Parrado, A

Biol Open 2015
14675773 Comparative functional analysis of the Rac GTPases

Haeusler, LC, Blumenstein, L, Stege, P, Dvorsky, R, Ahmadian, MR

FEBS Lett. 2003
11704860 The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3

De Toledo, M, Coulon, V, Schmidt, S, Fort, P, Blangy, A

Oncogene 2001
28356423 Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells

Rosenberg, BJ, Gil-Henn, H, Mader, CC, Halo, T, Yin, T, Condeelis, J, Machida, K, Wu, YI, Koleske, AJ

Mol. Biol. Cell 2017
Catalyst Activity

guanyl-nucleotide exchange factor activity of RAC3 GEFs [cytosol]

Orthologous Events
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