RHOBTB1, like other members of RHOBTB family, RHOBTB2 and RHOBTB3, binds to CUL3 (cullin-3), a core component of the BTB-CUL3-RBX2 E3 ubiquitin ligase complex (Berthold et al. 2008). RHOBTB1 binds to ROCK1 and ROCK2, and ROCK-mediated phosphorylation of RHOBTB1 may regulate its association with CUL3 (Haga et al. 2019). RHOBTB1 has been proposed as a substrate adaptor for PDE5, targeting it to CUL3 complexes for ubiquitination (Mukohda et al. 2019).
Mukohda, M, Fang, S, Wu, J, Agbor, LN, Nair, AR, Ibeawuchi, SC, Hu, C, Liu, X, Lu, KT, Guo, DF, Davis, DR, Keen, HL, Quelle, FW, Sigmund, CD
Haga, RB, Garg, R, Collu, F, Borda D'Agua, B, Menéndez, ST, Colomba, A, Fraternali, F, Ridley, AJ
Berthold, J, Schenkova, K, Ramos, S, Miura, Y, Furukawa, M, Aspenström, P, Rivero, F
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