RHOBTB1 binds interacting proteins at the endosome membrane

Stable Identifier
R-HSA-9018778
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RHOBTB1, like other members of RHOBTB family, RHOBTB2 and RHOBTB3, binds to CUL3 (cullin-3), a core component of the BTB-CUL3-RBX2 E3 ubiquitin ligase complex (Berthold et al. 2008). RHOBTB1 binds to ROCK1 and ROCK2, and ROCK-mediated phosphorylation of RHOBTB1 may regulate its association with CUL3 (Haga et al. 2019). RHOBTB1 has been proposed as a substrate adaptor for PDE5, targeting it to CUL3 complexes for ubiquitination (Mukohda et al. 2019).

Literature References
PubMed ID Title Journal Year
30896450 RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

Mukohda, M, Fang, S, Wu, J, Agbor, LN, Nair, AR, Ibeawuchi, SC, Hu, C, Liu, X, Lu, KT, Guo, DF, Davis, DR, Keen, HL, Quelle, FW, Sigmund, CD

J Clin Invest 2019
31431478 RhoBTB1 interacts with ROCKs and inhibits invasion

Haga, RB, Garg, R, Collu, F, Borda D'Agua, B, Menéndez, ST, Colomba, A, Fraternali, F, Ridley, AJ

Biochem. J. 2019
18835386 Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism

Berthold, J, Schenkova, K, Ramos, S, Miura, Y, Furukawa, M, Aspenström, P, Rivero, F

Exp. Cell Res. 2008
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