RHOBTB1 binds GTP

Stable Identifier
R-HSA-9018774
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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RHOBTB1 shares 80% sequence identity with RHOBTB2, with close to 95% identity in the GTPase domain (reviewed by Ji and Rivero 2016). Based on studies in RHOBTB2 (Manjarrez et al. 2014), as well as on the primary structure of the GTPase domain, RHOBTB1 is expected to bind to GTP, but not to cycle between GTP- and GDP-bound states. There are no known RHOBTB1 GAPs.

Literature References
PubMed ID Title Journal Year
24608665 Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex

Manjarrez, JR, Sun, L, Prince, T, Matts, RL

PLoS ONE 2014
27314390 Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis

Ji, W, Rivero, F

Cells 2016
Participants
Participant Of
Orthologous Events
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