RHOBTB1 binds GTP

Stable Identifier
R-HSA-9018774
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
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RHOBTB1 binds GTP
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RHOBTB1 shares 80% sequence identity with RHOBTB2, with close to 95% identity in the GTPase domain (reviewed by Ji and Rivero 2016). Based on studies in RHOBTB2 (Manjarrez et al. 2014), as well as on the primary structure of the GTPase domain, RHOBTB1 is expected to bind to GTP, but not to cycle between GTP- and GDP-bound states. There are no known RHOBTB1 GAPs - DEBDC1B was reported to bind RHOBTB1 by Bagci et al. 2020, but its RHOBTB1-directed GAP activity has not been tested.
Literature References
PubMed ID Title Journal Year
27314390 Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis

Ji, W, Rivero, F

Cells 2016
24608665 Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex

Prince, T, Matts, RL, Manjarrez, JR, Sun, L

PLoS ONE 2014
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Output
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Orthologous Events
RHOBTB1 binds GTP (Bos taurus)
RHOBTB1 binds GTP (Canis familiaris)
RHOBTB1 binds GTP (Dictyostelium discoideum)
RHOBTB1 binds GTP (Drosophila melanogaster)
RHOBTB1 binds GTP (Gallus gallus)
RHOBTB1 binds GTP (Mus musculus)
RHOBTB1 binds GTP (Rattus norvegicus)
RHOBTB1 binds GTP (Sus scrofa)
RHOBTB1 binds GTP (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2020-03-06)
Reviewed
Fort, P  (2021-02-05)
Rivero Crespo, F  (2020-10-13)
Created
Orlic-Milacic, M  (2017-09-05)
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