GDIs bind RHOH

Stable Identifier
R-HSA-9018754
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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While RHOH is constitutively bound to GTP and not found in the GDP bound state, GDP dissociation inhibitors (GDIs), still interact with RHOH. GDIalpha, GDIbeta and GDIgamma bind to RHOH and presumably affect its translocation to the site of activity by sequestering it in the cytosol (Li et al. 2002). Binding of RHOH to RHO GDIs has been reported as weak (Fauré and Dagher 2001).

Literature References
PubMed ID Title Journal Year
11368848 Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)

Fauré, J, Dagher, MC

Biochimie 2001
11809807 The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function

Li, X, Bu, X, Lu, B, Avraham, H, Flavell, RA, Lim, B

Mol. Cell. Biol. 2002
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