While RHOH is constitutively bound to GTP and not found in the GDP bound state, GDP dissociation inhibitors (GDIs), still interact with RHOH. GDIalpha, GDIbeta and GDIgamma bind to RHOH and presumably affect its translocation to the site of activity by sequestering it in the cytosol (Li et al. 2002). Binding of RHOH to RHO GDIs has been reported as weak (Fauré and Dagher 2001).
Fauré, J, Dagher, MC
Li, X, Bu, X, Lu, B, Avraham, H, Flavell, RA, Lim, B
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