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p-Y-NICD3 [cytosol]
Stable Identifier
R-HSA-9018581
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y-NOTCH3(1662-2321), p-Y-N3ICD
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9R1P4 Psma1
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
EGFR phosphorylates NOTCH3 (Homo sapiens)
p-Y-NICD3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UM47 NOTCH3
Gene Names
NOTCH3
Chain
signal peptide:1-39, chain:40-2321, chain:1629-2321, chain:1662-2321
Reference Genes
BioGPS Gene:4854 NOTCH3
COSMIC (genes):NOTCH3 NOTCH3
CTD Gene:4854 NOTCH3
dbSNP Gene:4854 NOTCH3
ENSEMBL:ENSG00000074181 NOTCH3
ENSEMBL_homo_sapiens_GENE:ENSG00000074181.9 NOTCH3
HGNC:7883 NOTCH3
KEGG Gene (Homo sapiens):4854 NOTCH3
Monarch:4854 NOTCH3
NCBI Gene:4854 NOTCH3
OMIM:600276 NOTCH3
UCSC:Q9UM47 NOTCH3
Reference Transcript
RefSeq:NM_000435.2 NOTCH3
Other Identifiers
11716569_at
11716570_a_at
16869769
203237_PM_s_at
203237_s_at
203238_PM_s_at
203238_s_at
3853111
3853112
3853113
3853114
3853115
3853116
3853117
3853118
3853119
3853120
3853121
3853122
3853123
3853124
3853126
3853127
3853128
3853129
3853130
3853131
3853133
3853134
3853135
3853136
3853137
3853138
3853139
3853140
3853141
3853142
3853143
3853145
3853146
3853147
3853148
3853150
3853151
3853152
3853153
3853154
3853157
3853158
3853159
3853160
3853161
3853162
3853163
3853164
3853166
3853167
3853168
3853169
3853170
3853173
3853174
3853175
38750_at
4854
8034940
A_33_P3313055
GE79373
GO:0000122
GO:0000139
GO:0005509
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0007219
GO:0007275
GO:0007411
GO:0009986
GO:0014016
GO:0016020
GO:0019899
GO:0023052
GO:0030154
GO:0030182
GO:0030900
GO:0038023
GO:0042802
GO:0043226
GO:0043235
GO:0045296
GO:0045596
GO:0045665
GO:0045944
GO:0048661
GO:0048663
GO:0048844
GO:0048856
GO:0050793
GO:0060089
GO:0072104
GO:1902895
HMNXSV003010299
Hs.8546.0.A1_3p_a_at
ILMN_1658926
PH_hs_0000907
TC19001250.hg
g4557798_3p_a_at
Participates
as an output of
EGFR phosphorylates NOTCH3 (Homo sapiens)
Other forms of this molecule
Ub-NICD3 [cytosol]
Ub-NEXT3 [plasma membrane]
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
NOTCH3(40-1628) [extracellular region]
NOTCH3(1629-1661) [plasma membrane]
NEXT3 [plasma membrane]
NICD3 [cytosol]
NICD3 [nucleoplasm]
Pre-NOTCH3 [endoplasmic reticulum membrane]
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
NOTCH3(1572-2321) [plasma membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
NOTCH3(1572-2321) [Golgi membrane]
Inferred To
phospho-Notch3 [cytosol]
(Mus musculus)
phospho-Notch3 [cytosol]
(Rattus norvegicus)
phospho-p-Y-NICD3 [cytosol]
(Gallus gallus)
phospho-p-Y-NICD3 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000426.2
Guide to Pharmacology - Targets
2860
OpenTargets
ENSG00000074181
ZINC - Substances
NOTC3_HUMAN
ZINC target
Q9UM47
PRO
Q9UM47
PDB
5CZV
,
5CZX
,
4ZLP
,
8OS0
,
6WQU
,
6XSW
HPA
ENSG00000074181-NOTCH3
GeneCards
Q9UM47
Ensembl
ENST00000263388
,
ENSG00000074181
,
ENSP00000263388
Pharos - Targets
Q9UM47
ZINC - Predictions - Purchasable
NOTC3_HUMAN
Orphanet
16559
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.643
5
UniProt:Q9UM47 NOTCH3
20
Ub-NICD3 [cytosol]
(R-HSA-9021546)
Ub-NEXT3 [plasma membrane]
(R-HSA-9021545)
p-Y-NICD3 [cytosol]
(R-HSA-9018581)
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911429)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911419)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911504)
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
(R-HSA-1911517)
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
(R-HSA-1911522)
NOTCH3(40-1628) [extracellular region]
(R-HSA-157639)
NOTCH3(1629-1661) [plasma membrane]
(R-HSA-157657)
NEXT3 [plasma membrane]
(R-HSA-157203)
NICD3 [cytosol]
(R-HSA-157647)
NICD3 [nucleoplasm]
(R-HSA-157928)
Pre-NOTCH3 [endoplasmic reticulum membrane]
(R-HSA-157102)
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467382)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467307)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
(R-HSA-1472871)
NOTCH3(1572-2321) [plasma membrane]
(R-HSA-157231)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
(R-HSA-1983675)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
(R-HSA-1983672)
0.558
2
UniProt:P86480 PR20D
0.556
3
UniProt:O60637 TSN3
0.527
2
UniProt:P59665 DEFA1
9
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
0.527
2
UniProt:Q9NZL3 ZNF224
1
ZNF224 [nucleoplasm]
(R-HSA-1027352)
0.527
2
UniProt:Q8IXB1 DJC10
0.527
2
UniProt:Q06330 RBPJ
1
RBPJ [nucleoplasm]
(R-HSA-3008668)
0.527
2
UniProt:Q9BZ11 ADAM33
1
ADAM33 [plasma membrane]
(R-HSA-708324)
0.527
2
UniProt:Q8TC27 ADA32
0.527
2
UniProt:Q9H8J5 MANS1
0.527
2
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.527
2
UniProt:Q8N8Y5 ZFP41
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:Q8WUM9 SLC20A1
1
SLC20A1 [plasma membrane]
(R-HSA-427600)
0.527
2
UniProt:Q9Y3R4 NEU2
1
NEU2 [cytosol]
(R-HSA-1605759)
0.527
3
UniProt:P15260 IFNGR1
2
IFNGR1 [plasma membrane]
(R-HSA-629623)
p-Y457-IFNGR1 [plasma membrane]
(R-HSA-873798)
0.527
2
UniProt:Q9R1P4 Psma1
2
Psma1 [nucleoplasm]
(R-MMU-9008778)
Psma1 [cytosol]
(R-MMU-1236802)
0.508
2
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