Estrogen-responsive EBAG9 gene expression

Stable Identifier
R-HSA-9018505
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Estrogen-responsive EBAG9 gene expression
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EBAG9, also known as RCAS1, is an estrogen-responsive gene with an ERE in the 5' flanking region. This element is bound by estrogen and ESR1 to stimulate transcription, as assessed by electrophoretic mobility shift and luciferase assay (Ikeda et al, 2000). EBAG9 may play a role in immune response during tumorigenesis, and expression of EBAG9 is often upregulated in malignant tumors (Jóźwicki et al, 2015; Miyazaki et al, 2014; Xu et al, 2014; Tanaka et al, 2014; Wolf et al, 2010; Maeyama et al, 2011)
Literature References
PubMed ID Title Journal Year
24885040 Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma

Kitamura, R, Matsubara, R, Tanaka, H, Sasaguri, M, Nakamura, S, Kawano, S, Toyoshima, T, Goto, Y, Sonoda, K

J Transl Med 2014
25674852 Expression of RCAS1 correlates with urothelial bladder cancer malignancy

Siekiera, J, Jóźwicki, W, Brożyna, AA, Slominski, AT

Int J Mol Sci 2015
20570965 Role of EBAG9 protein in coat protein complex I-dependent glycoprotein maturation and secretion processes in tumor cells

Rehm, A, Gerlach, K, Rüder, C, Dörken, B, Schuck, S, Otto, A, Wolf, J, Reimer, TA, Müller, EC

FASEB J. 2010
10873660 Promoter analysis and chromosomal mapping of human EBAG9 gene

Tsutsumi, O, Sato, M, Inazawa, J, Emi, M, Tsuneizumi, M, Ikeda, K, Tsuchiya, F, Muramatsu, M, Inoue, S, Imoto, I

Biochem. Biophys. Res. Commun. 2000
21573489 Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region

Maeyama, Y, Iimura, Y, Kubo, S, Kondo, S, Onodera, M, Sakiyama, Y, Yamano, T, Otsu, M, Ariga, T

Int. J. Oncol. 2011
25296600 Serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a diagnostic and prognostic marker for non-small cell lung cancer

Xu, C, Yu, LK, Zhang, X

Tumori 2014
25365482 EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes

Miyazaki, T, Kondo, T, Takahashi, S, Ikeda, K, Horie-Inoue, K, Inoue, S

Oncogenesis 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
EBAG9 gene:ESR1:ESTG [nucleoplasm] (Homo sapiens)
Active Unit
ESR1 dimer:ESTG [nucleoplasm]
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-09-01)
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