ESR1:ESTG bind the EBAG9 5' region

Stable Identifier
Reaction [binding]
Homo sapiens
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EBAG9 is an estrogen-responsive gene with an ill-characterized role in tumorigenesis and is overexpressed in a number of cancers (Jóźwicki et al, 2015; Xu et al, 2014; Giagnis et al, 2013). EBAG9 has been implicated in glycan maturation at the Golgi, and may also play roles in immune response and apoptosis during tumor growth (Wolf et al, 2010; Miyazaki et al, 2014; Tanaka et al, 2014; Mayeama et al, 2011). Estrogen-dependent transcription is mediated by an ERE in the 5'-flanking region which has been shown to bind ESR1 by electrophoretic mobility shift assay (Ikeda et al, 2000).
Literature References
PubMed ID Title Journal Year
24167369 Increased RCAS1 expression is associated with advanced histopathological stage and poor prognosis in patients with gastric adenocarcinoma

Efkarpidis, T, Kouraklis, G, Theocharis, S, Alexandrou, P, Giaginis, C, Patsouris, E

Dis. Markers 2013
24885040 Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma

Kitamura, R, Matsubara, R, Tanaka, H, Sasaguri, M, Nakamura, S, Kawano, S, Toyoshima, T, Goto, Y, Sonoda, K

J Transl Med 2014
25674852 Expression of RCAS1 correlates with urothelial bladder cancer malignancy

Siekiera, J, Jóźwicki, W, Brożyna, AA, Slominski, AT

Int J Mol Sci 2015
20570965 Role of EBAG9 protein in coat protein complex I-dependent glycoprotein maturation and secretion processes in tumor cells

Rehm, A, Gerlach, K, Rüder, C, Dörken, B, Schuck, S, Otto, A, Wolf, J, Reimer, TA, Müller, EC

FASEB J. 2010
21573489 Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region

Maeyama, Y, Iimura, Y, Kubo, S, Kondo, S, Onodera, M, Sakiyama, Y, Yamano, T, Otsu, M, Ariga, T

Int. J. Oncol. 2011
25296600 Serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a diagnostic and prognostic marker for non-small cell lung cancer

Xu, C, Yu, LK, Zhang, X

Tumori 2014
25365482 EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes

Miyazaki, T, Kondo, T, Takahashi, S, Ikeda, K, Horie-Inoue, K, Inoue, S

Oncogenesis 2014
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