Reactome | ESR1:ESTG and EP300 are recruited to TFF3 promoter

ESR1:ESTG and EP300 are recruited to TFF3 promoter

Stable Identifier

R-HSA-9018499

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ESR1:ESTG and EP300 are recruited to TFF3 promoter

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TFF3 is an estrogen-responsive gene whose expression is primed prior to estrogen receptor binding by the formation of FOXA1- and GATA3-dependent chromatin loops. Interaction of ligand-bound ESR1 with the enhancer promotes recruitment of EP300 and other chromatin modifiying enzymes, and stimulates the deposition of active chromatin marks like H3K4 methylation and H3K27 acteylation (Laganière et al, 2005; Theodorou et al, 2013; reviewed in Zaret and Carroll, 2011)

Literature References

PubMed ID	Title	Journal	Year
16087863	From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response Bataille, AR, Giguère, V, Robert, F, Lefebvre, C, Laganière, J, Deblois, G	Proc. Natl. Acad. Sci. U.S.A.	2005
22056668	Pioneer transcription factors: establishing competence for gene expression Zaret, KS, Carroll, JS	Genes Dev.	2011
23172872	GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility Stark, R, Menon, S, Carroll, JS, Theodorou, V	Genome Res.	2013