Reactome | ESR1:ESTG binds CXXC5 gene

ESR1:ESTG binds CXXC5 gene

Stable Identifier

R-HSA-9018325

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ESR1 binds to an ERE at -242 in the promoter of the CXXC5 gene and promotes transcription in an estrogen-dependent fashion. CXXC5 is a member of the zinc finger CXXC family of transcription factors and plays roles in cellular proliferation and differentiation (Nott et al, 2009; Yaşar et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
19321454	Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations Huang, Y, Welshons, WV, Fluharty, BR, Yeh, S, Qiu, X, Muyan, M, Li, X, Nott, SL	J. Biol. Chem.	2009
27886276	Estradiol-Estrogen Receptor α Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway Muyan, M, Ayaz, G, Yaşar, P	Sci Rep	2016

Participants

Input

Output

CXXC5 gene:ESR1:ESTG [nucleoplasm] (Homo sapiens)

Participates

as an event of

Estrogen-dependent gene expression (Homo sapiens)

Authored

Rothfels, K (2017-09-29)

Reviewed

Magnani, L (2018-02-23)

Created

Rothfels, K (2017-08-30)

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