Gamma-secretase cleaves YBX1:NOTCH3

Stable Identifier
R-HSA-9017817
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Gamma-secretase cleaves YBX1:NOTCH3
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Binding of NOTCH3 to YBX1 (YB-1) triggers cleavage of NOTCH3 by the gamma-secretase complex. The exact steps of YBX1-mediated NOTCH3 activation are not known. The gamma-secretase complex releases NOTCH3 intracellular domain (NICD3), leading to activation of NOTCH3 target genes downstream of YBX1 (Rauen et al. 2009).
Literature References
PubMed ID Title Journal Year
19640841 YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation

Rauen, T, Raffetseder, U, Frye, BC, Djudjaj, S, Mühlenberg, PJ, Eitner, F, Lendahl, U, Bernhagen, J, Dooley, S, Mertens, PR

J. Biol. Chem. 2009
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
Notch receptor processing, ligand-dependent (0035333)
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Physical Entity
gamma-secretase complex [plasma membrane] (Homo sapiens)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Orthologous Events
Gamma-secretase cleaves YBX1:NOTCH3 (Gallus gallus)
Gamma-secretase cleaves YBX1:NOTCH3 (Mus musculus)
Gamma-secretase cleaves YBX1:NOTCH3 (Rattus norvegicus)
Gamma-secretase cleaves YBX1:NOTCH3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-08-26)
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