Gamma-secretase cleaves YBX1:NOTCH3

Stable Identifier
R-HSA-9017817
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of NOTCH3 to YBX1 (YB-1) triggers cleavage of NOTCH3 by the gamma-secretase complex. The exact steps of YBX1-mediated NOTCH3 activation are not known. The gamma-secretase complex releases NOTCH3 intracellular domain (NICD3), leading to activation of NOTCH3 target genes downstream of YBX1 (Rauen et al. 2009).
Literature References
PubMed ID Title Journal Year
19640841 YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation

Djudjaj, S, Mühlenberg, PJ, Raffetseder, U, Frye, BC, Eitner, F, Bernhagen, J, Lendahl, U, Mertens, PR, Dooley, S, Rauen, T

J. Biol. Chem. 2009
Participants
Participates
Event Information
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!