Reactome | Noncanonical activation of NOTCH3

Noncanonical activation of NOTCH3

Stable Identifier

R-HSA-9017802

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Besides DLL/JAG ligands, NOTCH3 signaling can also be activated by binding of NOTCH3 to YBX1 (YB 1) (Rauen et al. 2009). YBX1, a protein involved in mRNA processing, is secreted by mesangial cells and monocytes during inflammation and acts as an extracellular mitogen (Frye et al. 2009). YBX1 triggers the gamma secretase complex mediated cleavage of NOTCH3, resulting in release of NOTCH3 intracellular domain (NICD3) and activation of NOTCH3 target genes (Rauen et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19483673	Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen Djudjaj, S, Muehlenberg, P, En-Nia, A, Raffetseder, U, Halfter, S, Frye, BC, Baron, JM, Knott, H, Bernhagen, J, Weber, S, Mertens, PR, Dooley, S	EMBO Rep.	2009
19640841	YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation Djudjaj, S, Mühlenberg, PJ, Raffetseder, U, Frye, BC, Eitner, F, Bernhagen, J, Lendahl, U, Mertens, PR, Dooley, S, Rauen, T	J. Biol. Chem.	2009