YBX1 (YB-1) binds to EGF repeats in the extracellular domain of NOTCH3 (Rauen et al. 2009). While YBX1 is extensively studied as a protein involved in mRNA processing, it is also secreted by mesangial cells and monocytes during inflammation and can act as an extracellular mitogen (Frye et al. 2009).
Djudjaj, S, Mühlenberg, PJ, Raffetseder, U, Frye, BC, Eitner, F, Bernhagen, J, Lendahl, U, Mertens, PR, Dooley, S, Rauen, T
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