NOTCH3 binds YBX1

Stable Identifier
R-HSA-9017797
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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NOTCH3 binds YBX1
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YBX1 (YB-1) binds to EGF repeats in the extracellular domain of NOTCH3 (Rauen et al. 2009). While YBX1 is extensively studied as a protein involved in mRNA processing, it is also secreted by mesangial cells and monocytes during inflammation and can act as an extracellular mitogen (Frye et al. 2009).

Literature References
PubMed ID Title Journal Year
19640841 YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation

Rauen, T, Raffetseder, U, Frye, BC, Djudjaj, S, Mühlenberg, PJ, Eitner, F, Lendahl, U, Bernhagen, J, Dooley, S, Mertens, PR

J. Biol. Chem. 2009
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
Notch signaling pathway (0007219)
Orthologous Events
NOTCH3 binds YBX1 (Mus musculus)
NOTCH3 binds YBX1 (Rattus norvegicus)
NOTCH3 binds YBX1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-08-26)
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