RHOJ binds effectors at the plasma membrane

Stable Identifier
R-HSA-9017507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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Active GTP bound RHOJ binds the following effectors:
FMNL3 (Richards et al. 2015)
PAK1 (Vignal et al. 2000, Ho et al. 2012; Bagci et al. 2020)
PAK3 (Sundararaman et al. 2020)
WIP2 WASP complex, through direct interaction with WAS (WASP) (Vignal et al. 2000), WASL (Abe et al. 2003, Bagci et al. 2020) and WIPF2 (Bagci et al. 2020)

The following RHOJ effectors are annotated as candidates because the knowledge on their relationship with RHOJ is limited:
ARHGAP1 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARL13B (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42BPA (Bagci et al. 2020)
CDC42BPB (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
FNBP1L (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
GJA1 (Bagci et al. 2020)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK4 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

In the screen by Bagci et al. 2020, active RHOJ was found to interact with LBR and YKT6, two proteins that localize to the endoplasmic reticulum membrane. However, since RHOJ localization at the endoplasmic reticulum membrane has not been reported, these two interactions have not been annotated.

RHOJ does not interact with the following RHO GTPase effectors:
ARFGAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
CDC42EP2 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
CDC42SE2 (Bagci et al. 2020)
FMNL1 (Bagci et al. 2020)
FMNL2 (Bagci et al. 2020)
GFOD1 (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
KCTD3 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
ROCK1 (Bagci et al. 2020)
ROCK2 (Bagci et al. 2020)
SH3PXD2A (Bagci et al. 2020)
SHKBP1 (Bagci et al. 2020)
SLK (Bagci et al. 2020)
WDR81 (Bagci et al. 2020)
WDR91 (Bagci et al. 2020)
WIPF1 (Bagci et al. 2020)
WIPF3 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
26299518 The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin

Richards, M, Hetheridge, C, Mellor, H

Curr. Biol. 2015
32302585 RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis

Sundararaman, A, Fukushima, Y, Norman, JC, Uemura, A, Mellor, H

Curr. Biol. 2020
22971344 RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage

Ho, H, Aruri, J, Kapadia, R, Mehr, H, White, MA, Ganesan, AK

Cancer Res. 2012
12456725 Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth

Abe, T, Kato, M, Miki, H, Takenawa, T, Endo, T

J. Cell. Sci. 2003
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
10967094 Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

Vignal, E, De Toledo, M, Comunale, F, Ladopoulou, A, Gauthier-Rouvière, C, Blangy, A, Fort, P

J. Biol. Chem. 2000
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