Based on studies in mouse hepatocytes (Mann et al. 2011) and rat lung cells (Joss-Moore et al. 2011), transcription of the PPARG gene is inhibited by binding of MECP2 to PPARG promoter. Binding of MECP2 to the PPAR gene correlates with the appearance of repressive methylation marks on histones associated with the PPARG promoter (Mann et al. 2010).