Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NOTCH3 coactivator complex binds HEYL gene promoter
Stable Identifier
R-HSA-9017398
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
NOTCH3 coactivator complex binds HEYL gene promoter (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on the findings that the NOTCH3 coactivator complex component RBPJ (CSL) binds to RBPJ response elements in the promoter of the HEYL gene (Geimer Le Lay et al. 2014) and that HEYL gene expression is stimulated by NOTCH3 (Maier and Gessler 2000) and overlaps with NOTCH3 expression in vascular smooth muscle cells and the thymus (Leimeister et al. 2000), it can be concluded that the NOTCH3 coactivator complex binds the promoter of the HEYL gene.
Participants
Input
HEYL Gene [nucleoplasm]
(Homo sapiens)
NOTCH3 coactivator complex [nucleoplasm]
(Homo sapiens)
Output
NOTCH3 coactivator complex:HEYL gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
Event Information
Go Biological Process
positive regulation of transcription of Notch receptor target (0007221)
Inferred From
Notch3 coactivator complex binds the Heyl gene promoter (Mus musculus)
Authored
Orlic-Milacic, M (2017-09-20)
Reviewed
Haw, R (2017-10-30)
Created
Orlic-Milacic, M (2017-08-21)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text