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activated PDE1A [cytosol]
Stable Identifier
R-HSA-9014912
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 1A, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, PDE1A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
activated PDE1 dimers [cytosol] (Homo sapiens)
activated PDE1A dimer [cytosol] (Homo sapiens)
activated PDE1A [cytosol] (Homo sapiens)
cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
activated PDE1 dimers [cytosol] (Homo sapiens)
activated PDE1A dimer [cytosol] (Homo sapiens)
activated PDE1A [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
activated PDE1 dimers [cytosol] (Homo sapiens)
activated PDE1A dimer [cytosol] (Homo sapiens)
activated PDE1A [cytosol] (Homo sapiens)
cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
activated PDE1 dimers [cytosol] (Homo sapiens)
activated PDE1A dimer [cytosol] (Homo sapiens)
activated PDE1A [cytosol] (Homo sapiens)
General
Can hydrolyze both cAMP and cGMP
External Reference Information
External Reference
UniProt:P54750 PDE1A
Gene Names
PDE1A
Chain
chain:1-535
Reference Genes
BioGPS Gene:5136 P547504
COSMIC (genes):PDE1A PDE1A
CTD Gene:5136 PDE1A
dbSNP Gene:5136 PDE1A
ENSEMBL:ENSG00000115252 PDE1A
HGNC:8774 P547504
KEGG:hsa:5136 P547504
Monarch:5136 P547504
NCBI Gene:5136 P547504
OMIM:171890 P547504
UCSC:P54750 P547504
Reference Transcript
RefSeq:NM_001395259.2 P547504
RefSeq:XM_017004296.1 P547504
RefSeq:NM_001258313.3 P547504
RefSeq:XM_017004299.1 P547504
RefSeq:XM_017004302.1 P547504
RefSeq:XM_017004301.1 P547504
RefSeq:XM_017004298.1 P547504
RefSeq:XM_017004300.1 P547504
RefSeq:NM_001363871.4 P547504
RefSeq:NM_001395260.2 P547504
RefSeq:XM_017004297.1 P547504
RefSeq:NM_001003683.3 P547504
RefSeq:XM_017004295.1 P547504
RefSeq:NM_001395262.1 P547504
RefSeq:NM_001395263.1 P547504
RefSeq:NM_001395261.2 P547504
RefSeq:NM_001395258.2 P547504
RefSeq:NM_001258314.3 P547504
RefSeq:NM_005019.4 P547504
Participates
as a component of
activated PDE1A dimer [cytosol] (Homo sapiens)
Other forms of this molecule
PDE1A [cytosol]
Inferred To
Pde1a [cytosol]
(Mus musculus)
Pde1a [cytosol]
(Rattus norvegicus)
Pde4 [cytosol]
(Dictyostelium discoideum)
PDEalpha [cytosol]
(Plasmodium falciparum)
regA [cytosol]
(Dictyostelium discoideum)
Homologues of activated PDE1A [cytosol]
(Dictyostelium discoideum)
Homologues of activated PDE1A [cytosol]
(Plasmodium falciparum)
pde-1 [cytosol]
(Caenorhabditis elegans)
PDE1A [cytosol]
(Bos taurus)
PDE1A [cytosol]
(Canis familiaris)
PDE1A [cytosol]
(Sus scrofa)
pde3 [cytosol]
(Dictyostelium discoideum)
PDEdelta [cytosol]
(Plasmodium falciparum)
PDEgamma [cytosol]
(Plasmodium falciparum)
PDEbeta [cytosol]
(Plasmodium falciparum)
activated PDE1A [cytosol]
(Gallus gallus)
pde1a [cytosol]
(Xenopus tropicalis)
Pde1c [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001382191.1
,
NP_001382190.1
,
XP_016859791.1
,
XP_016859784.1
,
NP_001350800.1
,
NP_001003683.1
,
NP_001382189.1
,
NP_001382188.1
,
NP_001382187.1
,
NP_001382192.1
,
NP_005010.2
,
NP_001245243.1
,
NP_001245242.1
,
XP_016859786.1
,
XP_016859789.1
,
XP_016859785.1
,
XP_016859788.1
,
XP_016859790.1
,
XP_016859787.1
ZINC - World Drugs
PDE1A_HUMAN
Guide to Pharmacology - Targets
1294
OpenTargets
ENSG00000115252
ENSEMBL
ENSP00000387037
,
ENST00000358139
,
ENSP00000512258
,
ENSP00000350858
,
ENSP00000512257
,
ENST00000409365
,
ENST00000351439
,
ENSP00000309269
,
ENST00000482782
,
ENSG00000115252
,
ENSP00000386767
,
ENST00000435564
,
ENST00000410103
,
ENST00000495511
,
ENSP00000410309
ZINC - FDA approved
PDE1A_HUMAN
ZINC - Substances
PDE1A_HUMAN
ZINC - Biogenic
PDE1A_HUMAN
ZINC target
P54750
PRO
P54750
GlyGen
P54750
HPA
ENSG00000115252-PDE1A
GeneCards
PDE1A
Pharos - Targets
P54750
ZINC - Predictions - Purchasable
PDE1A_HUMAN
HMDB Protein
HMDBP00571
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