Reactome | activated PDE1A [cytosol]

activated PDE1A [cytosol]

Stable Identifier

R-HSA-9014912

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 1A, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, PDE1A_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        activated PDE1 dimers [cytosol] (Homo sapiens)
        
        activated PDE1A dimer [cytosol] (Homo sapiens)
        
        activated PDE1A [cytosol] (Homo sapiens)
        
        cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
        
        activated PDE1 dimers [cytosol] (Homo sapiens)
        
        activated PDE1A dimer [cytosol] (Homo sapiens)
        
        activated PDE1A [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        activated PDE1 dimers [cytosol] (Homo sapiens)
        
        activated PDE1A dimer [cytosol] (Homo sapiens)
        
        activated PDE1A [cytosol] (Homo sapiens)
        
        cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
        
        activated PDE1 dimers [cytosol] (Homo sapiens)
        
        activated PDE1A dimer [cytosol] (Homo sapiens)
        
        activated PDE1A [cytosol] (Homo sapiens)

General

Can hydrolyze both cAMP and cGMP

External Reference Information

External Reference

UniProt:P54750 PDE1A

Gene Names

PDE1A

Chain

chain:1-535

Reference Genes

BioGPS Gene:5136 PDE1A

COSMIC (genes):PDE1A PDE1A

CTD Gene:5136 PDE1A

dbSNP Gene:5136 PDE1A

ENSEMBL:ENSG00000115252.18 PDE1A

HGNC:8774 PDE1A

KEGG Gene (Homo sapiens):5136 PDE1A

Monarch:5136 PDE1A

NCBI Gene:5136 PDE1A

OMIM:171890 PDE1A

UCSC:P54750 PDE1A

Reference Transcript

Other Identifiers

0005290088

0106350309

11733358_a_at

11734814_a_at

1558680_PM_s_at

1558680_s_at

16906140

208396_PM_s_at

208396_s_at

231213_PM_at

231213_at

233547_PM_x_at

233547_x_at

236234_PM_at

236234_at

242789_PM_at

242789_at

2590585

2590586

2590587

2590591

2590599

2590600

2590601

2590606

2590607

2590608

2590611

2590612

2590613

2590614

2590615

2590616

2590617

2590618

2590619

2590620

2590628

2590645

2590646

2590661

2590662

2590663

2590664

2590667

2590668

36311_at

49109_at

5136

59445_at

79873_at

8057486

A_23_P79272

A_24_P102082

A_24_P208436

GE56445

GO:0003674

GO:0004114

GO:0004115

GO:0004117

GO:0005515

GO:0005516

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0007165

GO:0008081

GO:0008150

GO:0016787

GO:0023052

GO:0043025

GO:0043167

GO:0046872

GO:0047555

GO:0048101

HMNXSV003002063

HMNXSV003055781

Hs.145173.0.A1_3p_at

Hs.167708.0.S1_3p_at

Hs.22467.0.S1_3p_at

Hs.41717.2.S1_3p_a_at

Hs2.383511.1.S1_3p_s_at

ILMN_1716350

ILMN_1775163

ILMN_1778924

ILMN_1805564

ILMN_2376847

TC02002590.hg

TC02004734.hg

TC02004735.hg

U40370_at

g4826891_3p_a_at

Participates

as a component of

activated PDE1A dimer [cytosol] (Homo sapiens)

Other forms of this molecule

PDE1A [cytosol]

Inferred To

activated PDE1A [cytosol] (Bos taurus)

activated PDE1A [cytosol] (Caenorhabditis elegans)

activated PDE1A [cytosol] (Canis familiaris)

activated PDE1A [cytosol] (Danio rerio)

activated PDE1A [cytosol] (Dictyostelium discoideum)

activated PDE1A [cytosol] (Drosophila melanogaster)

activated PDE1A [cytosol] (Gallus gallus)

activated PDE1A [cytosol] (Mus musculus)

activated PDE1A [cytosol] (Plasmodium falciparum)

activated PDE1A [cytosol] (Rattus norvegicus)

activated PDE1A [cytosol] (Sus scrofa)

activated PDE1A [cytosol] (Xenopus tropicalis)

Homologues of activated PDE1A [cytosol] (Plasmodium falciparum)

Cross References

RefSeq

NP_001003683.1, XP_016859784.1, XP_016859786.1, XP_016859788.1, XP_016859791.1, NP_001245242.1, XP_016859785.1, NP_005010.2, XP_016859787.1, XP_016859789.1, NP_001245243.1, XP_016859790.1

ZINC - World Drugs

PDE1A_HUMAN

Guide to Pharmacology - Targets

1294

OpenTargets

ENSG00000115252

ZINC - FDA approved

PDE1A_HUMAN

ZINC - Substances

PDE1A_HUMAN

ZINC target

P54750

ZINC - Biogenic

PDE1A_HUMAN

PRO

P54750

GeneCards

P54750

HPA

ENSG00000115252-PDE1A

Ensembl

ENSP00000309269, ENSP00000410309, ENSP00000386767, ENSP00000350858, ENST00000358139, ENST00000351439, ENST00000435564, ENSP00000387037, ENST00000409365, ENST00000410103, ENSG00000115252

Pharos - Targets

P54750

ZINC - Predictions - Purchasable

PDE1A_HUMAN

HMDB Protein

HMDBP00571