Reactome | RHOG binds effectors at the ER membrane

RHOG binds effectors at the ER membrane

Stable Identifier

R-HSA-9014467

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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Active GTP-bound RHOG binds to and activates kinectin (KTN1) at the endoplasmic reticulum membrane (Vignal et al. 2001).

In addition, active RHOG binds to the following candidate endoplasmic reticulum membrane effectors identified in the high throughput screen by Bagci et al. 2020:
ANKLE2 (Bagci et al. 2020)
EMD (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
LEMD3 (Bagci et al. 2020)
LETM1 (Bagci et al. 2020)
LMAN1 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
PGRMC2 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)
VRK2 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
11689693	Kinectin is a key effector of RhoG microtubule-dependent cellular activity Blangy, A, Gauthier-Rouvière, C, Vignal, E, Martin, M, Fort, P	Mol. Cell. Biol.	2001
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020