Reactome | GDIs block activation of RHOG

GDIs block activation of RHOG

Stable Identifier

R-HSA-9014456

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The following GDP dissociation inhibitors (GDIs) bind to RHOG and inhibit its activation:
ARHGDIA (Elfenbein et al. 2009)
ARHGDIB (Vignal et al. 2001)
ARHGDIG (Zalcman et al. 1996; Brunet et al. 2002)

Literature References

PubMed ID	Title	Journal	Year
11689693	Kinectin is a key effector of RhoG microtubule-dependent cellular activity Blangy, A, Gauthier-Rouvière, C, Vignal, E, Martin, M, Fort, P	Mol. Cell. Biol.	2001
11967128	RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain Morin, A, Brunet, N, Olofsson, B	Traffic	2002
19581409	Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway Matsuda, M, Rhodes, JM, Meller, J, Simons, M, Elfenbein, A, Schwartz, MA	J. Cell Biol.	2009
8939998	RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG Honoré, N, Olofsson, B, Camonis, J, Rousseau-Merck, MF, Zalcman, G, Closson, V, Tavitian, A	J. Biol. Chem.	1996