Reactome | RHOG binds effectors at the plasma membrane

RHOG binds effectors at the plasma membrane

Stable Identifier

R-HSA-9014449

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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General

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RHOG binds effectors at the plasma membrane

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Activated GTP bound RHOG binds to the following effectors at the plasma membrane:
DOCK1 (Katoh et al. 2006, Bagci et al. 2020)
DOCK2 (Damoulakis et al. 2014)
DOCK3 (Namekata et al. 2012)
DOCK4 (Hiramoto‑Yamaki et al. 2010, Hiramoto et al. 2006, Bagci et al. 2020 )
IQGAP2 (Wennerberg et al. 2002)
MAP3K11 (Wennerberg et al. 2002)
PLEKHG3 (Bagci et al. 2020)
PLD1 (Wennerberg et al. 2002)

The following candidate effectors that localize to the plasma membrane or cytosol have been found to bind to active RHOG in the high throughput screen by Bagci et al. 2020:
ARFGAP3 (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CYFIP1 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
DOCK5 (Bagci et al. 2020)
DSG2 (Bagci et al. 2020)
ELMO2 (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
HSPE1 (Bagci et al. 2020)
ITGB1 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
NDUFS3 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK4 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SHMT2 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Activated RHOG does not act on or does not bind to the following putative effectors in the high throughput screen by Bagci et al. 2020:
ABI1 (Bagci et al. 2020)
ABI2 (Bagci et al. 2020)
ABL2 (Bagci et al. 2020)
AMIGO2 (Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARMCX3 (Bagci et al. 2020)
BAIAP2 (Wennerberg et al. 2002, Bagci et al. 2020)
BAIAP2L1 (Bagci et al. 2020)
BRK1 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
FERMT2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IL32 (Bagci et al. 2020)
JAG1 (Bagci et al. 2020)
NCKAP1 (Bagci et al. 2020)
NHS (Bagci et al. 2020)
PAK1 (Wennerberg et al. 2002)
PAK5 (Wennerberg et al. 2002)
PAK6 (Wennerberg et al. 2002)
PARD6A (Wennerberg et al. 2002)
PLEKHG4 (Bagci et al. 2020)
RAPGEF1 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLITRK3 (Bagci et al. 2020)
SLITRK5 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SWAP70 (Bagci et al. 2020)
TAOK3 (Bagci et al. 2020)
WAS (WASP) (Wennerberg et al. 2002)
WASF1 (Bagci et al. 2020)
WASF2 (Bagci et al. 2020)

Activated RHOG interacts with the WAVE complex component CYFIP1 (Bagci et al. 2020), but not with the WAVE complex components WASF1 and WASF2 (Bagci et al. 2020). The WAVE complex is not annotated as a RHOG effector.

Literature References

PubMed ID	Title	Journal	Year
22734669	Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG Harada, T, Watanabe, H, Namekata, K, Kimura, A, Guo, X, Harada, C, Kawamura, K, Kittaka, D	Genes Cells	2012
17027967	Dock4 is regulated by RhoG and promotes Rac-dependent cell migration Hiramoto, K, Katoh, H, Negishi, M	Exp Cell Res	2006
12376551	RhoG signals in parallel with Rac1 and Cdc42 Burridge, K, Karnoub, AE, Ellerbroek, SM, Liu, RY, Wennerberg, K, Der, CJ	J. Biol. Chem.	2002
16339170	Activation of Rac1 by RhoG regulates cell migration Katoh, H, Negishi, M, Hiramoto, K	J. Cell. Sci.	2006
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020
24659802	P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils Fukui, Y, Damoulakis, G, Welch, HC, Anderson, KE, Rossman, KL, Hawkins, PT, Gambardella, L, Lawson, CD, Stephens, LR, Der, CJ	J. Cell. Sci.	2014
20679435	Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism Katoh, H, Ueda, S, Hiramoto-Yamaki, N, Takeuchi, S, Harada, K, Fujimoto, S, Negishi, M	J. Cell Biol.	2010