Reactome | RAC2 binds effectors at the phagocytic vesicle membrane

RAC2 binds effectors at the phagocytic vesicle membrane

Stable Identifier

R-HSA-9014424

Type

Reaction [binding]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane

ReviewStatus

5/5

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RAC2 binds effectors at the phagocytic vesicle membrane

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RAC2 binds to and activates the NOX2 complex and the phagocytic vesicle membrane (Knaus et al. 1991; Kim et al. 2001; Carstanjen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
11145705	Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways Kim, C, Dinauer, MC	J. Immunol.	2001
1660188	Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 Bokoch, GM, Curnutte, JT, Evans, T, Knaus, UG, Heyworth, PG	Science	1991
15814684	Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways Koornneef, A, Carstanjen, D, Yamauchi, A, Towe, J, Dinauer, MC, Zheng, Y, Harris, C, Atkinson, S, Filippi, MD, Williams, DA, Zang, H	J. Immunol.	2005