IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex

Stable Identifier
R-HSA-9014343
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
Synonyms
Nemo subunit of IKK complex binds polyubiquinated RIP1
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Structural studies showed that NEMO binds both Lys-63- and linear polyubiquitin chains,both critical for NF-kB activation.

Literature References
PubMed ID Title Journal Year
16547522 Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

Wu, CJ, Conze, DB, Li, T, Srinivasula, SM, Ashwell, JD

Nat Cell Biol 2006
16603398 Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

Ea, CK, Deng, L, Xia, ZP, Pineda, G, Chen, ZJ

Mol Cell 2006
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