RAC2 GEFs activate RAC2

Stable Identifier
R-HSA-9014296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC2 and catalyze GDP to GTP exchange on RAC2, resulting in formation of the active RAC2:GTP complex:
ABR (Chuang et al. 1995)
BCR (Chuang et al. 1995)
DEF6 (Mavrakis et al. 2004)
DOCK2 (Sai et al. 2008; Kwofie and Skowronski 2008 )
MCF2 (Jaiswal et al. 2013)
PREX1 (Welch et al. 2005; Dong et al. 2005; Barber et al. 2007; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003; Niebel et al. 2013; Jaiswal et al. 2013)
TRIO (Newsome et al. 2000; Hakeda-Suzuki et al. 2002; Jaiswal et al. 2013)
VAV1 (Ming et al. 2007; Miletic et al. 2007; Yin et al. 2011)
VAV2 (Arana et al. 2008; Jaiswal et al. 2013)
VAV3 (Flannagan et al. 2014)

The following GEFs are annotated as candidate RAC2 GEFs since they were shown to bind RAC2, but their ability to activate RAC2 has not been tested:
DOCK1 (Kwofie and Skowronski 2008)
DOCK3 (Kwofie and Skowronski 2008)
DOCK4 (Kwofie and Skowronski 2008)
DOCK10 (Ruiz-Lafuente et al. 2015)
SWAP70 (Sivalenka and Jessberger 2004)

The following RHO GEFs do not act on RAC2:
ARHGEF1 (Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2013)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF4 (Gotthardt and Ahmadian 2007; Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
DOCK9: (Kwofie and Skowronski 2008)
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)

Literature References
PubMed ID Title Journal Year
17698854 Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase

Barber, MA, Donald, S, Thelen, S, Anderson, KE, Thelen, M, Welch, HC

J. Biol. Chem. 2007
17060455 The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity

Ming, W, Li, S, Billadeau, DD, Quilliam, LA, Dinauer, MC

Mol. Cell. Biol. 2007
10847683 Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

Newsome, TP, Schmidt, S, Dietzl, G, Keleman, K, Asling, B, Debant, A, Dickson, BJ

Cell 2000
17214551 Asef is a Cdc42-specific guanine nucleotide exchange factor

Gotthardt, K, Ahmadian, MR

Biol. Chem. 2007
18662984 Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis

Sai, J, Raman, D, Liu, Y, Wikswo, J, Richmond, A

J. Biol. Chem. 2008
21151158 The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells

Yin, J, Wan, YJ, Li, SY, Du, MJ, Zhang, CZ, Zhou, XL, Cao, YJ

Acta Pharmacol. Sin. 2011
11919634 Rac function and regulation during Drosophila development

Hakeda-Suzuki, S, Ng, J, Tzu, J, Dietzl, G, Sun, Y, Harms, M, Nardine, T, Luo, L, Dickson, BJ

Nature 2002
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Jaiswal, M, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2013
15542837 SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration

Sivalenka, RR, Jessberger, R

Mol. Cell. Biol. 2004
16243036 P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

Dong, X, Mo, Z, Bokoch, G, Guo, C, Li, Z, Wu, D

Curr. Biol. 2005
11704860 The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3

De Toledo, M, Coulon, V, Schmidt, S, Fort, P, Blangy, A

Oncogene 2001
14675773 Comparative functional analysis of the Rac GTPases

Haeusler, LC, Blumenstein, L, Stege, P, Dvorsky, R, Ahmadian, MR

FEBS Lett. 2003
15023524 DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA

Mavrakis, KJ, McKinlay, KJ, Jones, P, Sablitzky, F

Exp. Cell Res. 2004
17158234 Vav proteins control MyD88-dependent oxidative burst

Miletic, AV, Graham, DB, Montgrain, V, Fujikawa, K, Kloeppel, T, Brim, K, Weaver, B, Schreiber, R, Xavier, R, Swat, W

Blood 2007
16243035 P-Rex1 regulates neutrophil function

Welch, HC, Condliffe, AM, Milne, LJ, Ferguson, GJ, Hill, K, Webb, LM, Okkenhaug, K, Coadwell, WJ, Andrews, SR, Thelen, M, Jones, GE, Hawkins, PT, Stephens, LR

Curr. Biol. 2005
18191593 Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation

Arana, E, Vehlow, A, Harwood, NE, Vigorito, E, Henderson, R, Turner, M, Tybulewicz, VL, Batista, FD

Immunity 2008
7479768 Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family

Chuang, TH, Xu, X, Kaartinen, V, Heisterkamp, N, Groffen, J, Bokoch, GM

Proc. Natl. Acad. Sci. U.S.A. 1995
25862245 Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells

Ruiz-Lafuente, N, Alcaraz-García, MJ, García-Serna, AM, Sebastián-Ruiz, S, Moya-Quiles, MR, García-Alonso, AM, Parrado, A

Biol Open 2015
18056264 Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors

Kwofie, MA, Skowronski, J

J. Biol. Chem. 2008
23757206 RNA-aptamers that modulate the RhoGEF activity of Tiam1

Niebel, B, Wosnitza, CI, Famulok, M

Bioorg. Med. Chem. 2013
24623723 The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

Flannagan, RS, Canton, J, Furuya, W, Glogauer, M, Grinstein, S

Mol. Biol. Cell 2014
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Catalyst Activity

guanyl-nucleotide exchange factor activity of RAC2 GEFs [cytosol]

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