activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]

Stable Identifier
R-HSA-9013982
Type
Complex
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
endosome membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
16281057 SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways

Liu, T, Chen, D, Xu, LG, Shu, HB, Zhai, Z, Huang, J

EMBO J 2005
16306936 Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Perry, A, Saha, SK, Oganesyan, G, He, JQ, Guo, B, Shahangian, A, Cheng, G, Zarnegar, B

Nature 2006
14530355 Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling

Kawai, T, Takeda, K, Sato, S, Akira, S, Watanabe, Y, Yamamoto, M, Sugiyama, M

J. Immunol. 2003
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