Auto-ubiquitination of TRAF3 within activated TLR3 complex

Stable Identifier
R-HSA-9013974
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
endosome membrane, cytosol
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Auto-ubiquitination of TRAF3 within activated TLR3 complex
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TRIF(TICAM1) signaling activates TRAF3 self-mediated polyubiquitination trough Lys-63 of ubiquitin. The ubiquitinated TRAF3 in turn activates the interferon response (Tseng PH et al. 2010).

Literature References
PubMed ID Title Journal Year
19898473 Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

Tseng, PH, Matsuzawa, A, Zhang, W, Mino, T, Vignali, DA, Karin, M

Nat Immunol 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]
Physical Entity
TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane]
Activity
ubiquitin-protein transferase activity (0004842)
Authored
Shamovsky, V  (2012-04-26)
Reviewed
D'Eustachio, P  (2012-05-25)
Fitzgerald, KA  (2012-11-13)
Masci, A M  (2014-05-16)
Created
Shamovsky, V  (2017-07-26)