TRIF(TICAM1) signaling activates TRAF3 self-mediated polyubiquitination trough Lys-63 of ubiquitin. The ubiquitinated TRAF3 in turn activates the interferon response (Tseng PH et al. 2010).
Tseng, PH, Matsuzawa, A, Zhang, W, Mino, T, Vignali, DA, Karin, M
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