HES1 gene expression is stimulated by NOTCH4

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R-HSA-9013711
Type
Reaction [omitted]
Species
Homo sapiens
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NOTCH4 expression correlates with increased HES1 gene transcription in different cell types (Raafat et al. 2004, Lai et al. 2013, Simoes et al. 2015). A recombinant human NICD4 stimulates transcription from the recombinant human HES1-luciferase reporter construct (Raafat et al. 2004).

Literature References
PubMed ID Title Journal Year
15531924 Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh)

Raafat, A, Bargo, S, Anver, MR, Callahan, R

Oncogene 2004
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