Reactome | HES1 gene expression is stimulated by NOTCH3 and STAT1

HES1 gene expression is stimulated by NOTCH3 and STAT1

Stable Identifier

R-HSA-9013567

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HES1 gene expression is stimulated by NOTCH3 and STAT1

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Based on studies in a mouse system, HES1 gene expression is directly stimulated by the NOTCH3 coactivator complex (Lin et al. 2002, Shimizu et al. 2002). Activated STAT1 directly enhances HES1 transcription induced by NICD3 (Boelens et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
11866432	Functional diversity among Notch1, Notch2, and Notch3 receptors Shimizu, K, Hirai, H, Kumano, K, Hamada, Y, Saito, T, Chiba, S	Biochem Biophys Res Commun	2002
12386158	Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling Oyama, T, Nagase, T, Lin, SE, Kitagawa, M, Harigaya, K	J. Biol. Chem.	2002
25417103	Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways Wiemann, BZ, Qiu, Y, Nabet, BY, Ishwaran, H, Wu, TJ, Slingerland, J, Twyman-Saint Victor, C, Xu, B, Minn, AJ, Yoon, T, Ter Brugge, PJ, Jonkers, J, Boelens, MC, Azzam, DJ	Cell	2014