Reactome | RHOD binds effectors at the endosome membrane

RHOD binds effectors at the endosome membrane

Stable Identifier

R-HSA-9013438

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOD binds effectors at the endosome membrane

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Active GTP-bound RHOD binds the following effectors at the endosome membrane:
ANKFY1 (Nehru et al. 2013)
DIAPH2-3 (DIAPH2 isoform C) (Gasman et al. 2003)

The following candidate effectors that can localize to endosomal membranes were reported to bind active RHOD by Bagci et al. 2020:
EMD (Bagci et al. 2020)
LBR (Bagci et al. 2020)
LEMD3 (Bagci et al. 2020)
MOSPD2 (Bagci et al. 2020)
PGRMC2 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
24102721	RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor Nehru, V, Voytyuk, O, Lennartsson, J, Aspenström, P	Traffic	2013
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF	Nat. Cell Biol.	2020
12577064	RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase Gasman, S, Kalaidzidis, Y, Zerial, M	Nat. Cell Biol.	2003