This pathway catalogues RHOG guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOG effectors. RHOG is a RAC-related RHO GTPase, ~70% identical to RAC1 (Vincent et al. 1992, de Curtis 2008). RHOG is broadly expressed in different tissue types. It regulates the cytoskeleton, acting either upstream of or in parallel to RAC1. RHOG regulates cell polarity, adhesion, migration and invasion, contributing to the formation of lamellipodia and invadopodia (Gauthier-Rouvière et al. 1998, Al-Koussa et al. 2020). The ortholog of RHOG is required for neuronal development in C. elegans (de Curtis 2008). RHOG is involved in VEGF signaling and angiogenesis (El Baba et al. 2020). RHOG cooperates with RAC1 and CDC42 in malignant cell transformation (Roux et al. 1997) and may contribute to invasiveness of cancer cells (Al-Koussa et al. 2020).
El Baba, N, Fakhoury, I, Khalil, EA, Jaafar, L, El-Sibai, M, Farran, M
Jaafar, L, El-Sibai, M, Al-Koussa, H, Atat, OE, Tashjian, H
Mériane, M, Gauthier-Rouvière, C, Vignal, E, Montcourier, P, Roux, P, Fort, P
Gauthier-Rouvière, C, Doucet-Brutin, S, Roux, P, Fort, P
de Curtis, I
Vincent, S, Jeanteur, P, Fort, P
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