Reactome | RHOG GTPase cycle

RHOG GTPase cycle

Stable Identifier

R-HSA-9013408

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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This pathway catalogues RHOG guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOG effectors. RHOG is a RAC-related RHO GTPase, ~70% identical to RAC1 (Vincent et al. 1992, de Curtis 2008). RHOG is broadly expressed in different tissue types. It regulates the cytoskeleton, acting either upstream of or in parallel to RAC1. RHOG regulates cell polarity, adhesion, migration and invasion, contributing to the formation of lamellipodia and invadopodia (Gauthier-Rouvière et al. 1998, Al-Koussa et al. 2020). The ortholog of RHOG is required for neuronal development in C. elegans (de Curtis 2008). RHOG is involved in VEGF signaling and angiogenesis (El Baba et al. 2020). RHOG cooperates with RAC1 and CDC42 in malignant cell transformation (Roux et al. 1997) and may contribute to invasiveness of cancer cells (Al-Koussa et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
32377503	The Role of Rho GTPases in VEGF Signaling in Cancer Cells El Baba, N, Fakhoury, I, Khalil, EA, Jaafar, L, El-Sibai, M, Farran, M	Anal Cell Pathol (Amst)	2020
32089990	The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells Jaafar, L, El-Sibai, M, Al-Koussa, H, Atat, OE, Tashjian, H	Anal Cell Pathol (Amst)	2020
9614181	RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs Mériane, M, Gauthier-Rouvière, C, Vignal, E, Montcourier, P, Roux, P, Fort, P	Mol Biol Cell	1998
9285711	The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells Gauthier-Rouvière, C, Doucet-Brutin, S, Roux, P, Fort, P	Curr Biol	1997
18075254	Functions of Rac GTPases during neuronal development de Curtis, I	Dev. Neurosci.	2008
1620121	Growth-regulated expression of rhoG, a new member of the ras homolog gene family Vincent, S, Jeanteur, P, Fort, P	Mol Cell Biol	1992