NEXT3 is cleaved to produce NICD3

Stable Identifier
R-HSA-9013361
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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NEXT3 is cleaved to produce NICD3
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NEXT3 fragment of NOTCH3 is further cleaved at the S3 site by the gamma-secretase complex, containing either PSEN1 (presenilin-1) or PSEN2 (presenilin-2) as the catalytic subunit, which releases the intracellular domain NICD3 into the cytosol (Groot et al. 2014).

Literature References
PubMed ID Title Journal Year
24842903 Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins

Groot, AJ, Habets, R, Vooijs, M, Saftig, P, Hodin, CM, Theys, J, Reiss, K, Yahyanejad, S

Mol. Cell. Biol. 2014
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
Notch receptor processing, ligand-dependent (0035333)
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Physical Entity
gamma-secretase complex [plasma membrane] (Homo sapiens)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Orthologous Events
NEXT3 is cleaved to produce NICD3 (Gallus gallus)
NEXT3 is cleaved to produce NICD3 (Mus musculus)
NEXT3 is cleaved to produce NICD3 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-07-24)
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