RAC1 GDIs block activation of RAC1

Stable Identifier
R-HSA-9013147
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The following GDP dissociation inhibitors (GDIs) bind to RAC1 and inhibit its activation:
ARHGDIA (Boulter et al. 2010; Gupta et al. 2013; Ando et al. 1992)
ARHGDIB (Adra et al. 1993, Zhang et al. 2009)

ARHGDIG does not act on RAC1 (Zalcman et al. 1996, Adra et al. 1997)

Literature References
PubMed ID Title Journal Year
9113980 RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas

Adra, CN, Manor, D, Ko, JL, Zhu, S, Horiuchi, T, Van Aelst, L, Cerione, RA, Lim, B

Proc Natl Acad Sci U S A 1997
7512369 Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I

Adra, CN, Ko, J, Leonard, D, Wirth, LJ, Cerione, RA, Lim, B

Genes Chromosomes Cancer 1993
20400958 Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

Boulter, E, Garcia-Mata, R, Guilluy, C, Dubash, A, Rossi, G, Brennwald, PJ, Burridge, K

Nat. Cell Biol. 2010
1464587 Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase

Ando, S, Kaibuchi, K, Sasaki, T, Hiraoka, K, Nishiyama, T, Mizuno, T, Asada, M, Nunoi, H, Matsuda, I, Matsuura, Y

J. Biol. Chem. 1992
19269969 Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling

Zhang, Y, Rivera Rosado, LA, Moon, SY, Zhang, B

J. Biol. Chem. 2009
23434736 ARHGDIA: a novel gene implicated in nephrotic syndrome

Gupta, IR, Baldwin, C, Auguste, D, Ha, KC, El Andalousi, J, Fahiminiya, S, Bitzan, M, Bernard, C, Akbari, MR, Narod, SA, Rosenblatt, DS, Majewski, J, Takano, T

J. Med. Genet. 2013
8939998 RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG

Zalcman, G, Closson, V, Camonis, J, Honoré, N, Rousseau-Merck, MF, Tavitian, A, Olofsson, B

J. Biol. Chem. 1996
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