Reactome | RHOB GTPase cycle

RHOB GTPase cycle

Stable Identifier

R-HSA-9013026

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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General

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This pathway catalogues RHOB guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOB effectors. RHOB belongs to the RHOA subfamily of RHO GTPases and shares 85% sequence identity with RHOA and RHOC. Posttranslational modifications of the unique C-terminus of RHOB regulate its subcellular localization. Similar to RHOA and RHOC, RHOB regulates the cytoskeleton and plays a role in cell migration. RHOB plays a role in regulation of membrane trafficking (Vega and Ridley 2018), cell proliferation (Vega and Ridley 2018), cell adhesion (Vega and Ridley 2018), DNA repair (Vega and Ridley 2018), and apoptosis (Prendergast 2001; Vega and Ridley 2018). RHOB-regulated cellular processes are important for the immune system function (Vega and Ridley 2018), pulmonary gas exchange (Wojciak-Stothard et al. 2012; Vega and Ridley 2018), and angiogenesis and vascular function (Vega and Ridley 2018). RHOB has been implicated both as a tumor suppressor and as an oncogene in cancer (Prendergast 2001; Huang and Prendergast 2006; Ju and Gilkes 2018; Calvayrac et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
22539766	Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia Wojciak-Stothard, B, Zhao, L, Oliver, E, Dubois, O, Wu, Y, Kardassis, D, Vasilaki, E, Huang, M, Mitchell, JA, Harrington, LS, Louise, H, Prendergast, GC, Wilkins, MR	Circ. Res.	2012
27875099	The RhoB small GTPase in physiology and disease Vega, FM, Ridley, AJ	Small GTPases	2018
27676292	RHOB expression controls the activity of serine/threonine protein phosphatase PP2A to modulate mesenchymal phenotype and invasion in non-small cell lung cancers Calvayrac, O, Pradines, A, Favre, G	Small GTPases	2018
11905808	Actin' up: RhoB in cancer and apoptosis Prendergast, GC	Nat. Rev. Cancer	2001
16329046	RhoB in cancer suppression Huang, M, Prendergast, GC	Histol. Histopathol.	2006
29385717	RhoB: Team Oncogene or Team Tumor Suppressor? Ju, JA, Gilkes, DM	Genes (Basel)	2018