GDIs block activation of RHOB

Stable Identifier
R-HSA-9013021
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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GDIs block activation of RHOB
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ARHGDIG is a GDP dissociation inhibitor (GDI) that binds to RHOB and inhibits its activation (Zalcman et al. 1996). Binding of other GDIs to RHOB has not been tested.
Literature References
PubMed ID Title Journal Year
8939998 RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG

Honoré, N, Olofsson, B, Camonis, J, Rousseau-Merck, MF, Zalcman, G, Closson, V, Tavitian, A

J. Biol. Chem. 1996
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Orthologous Events
GDIs block activation of RHOB (Caenorhabditis elegans)
GDIs block activation of RHOB (Canis familiaris)
GDIs block activation of RHOB (Drosophila melanogaster)
GDIs block activation of RHOB (Mus musculus)
GDIs block activation of RHOB (Rattus norvegicus)
GDIs block activation of RHOB (Saccharomyces cerevisiae)
GDIs block activation of RHOB (Schizosaccharomyces pombe)
GDIs block activation of RHOB (Sus scrofa)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Created
Orlic-Milacic, M  (2017-07-21)
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