RHOA binds effectors at the ER membrane

Stable Identifier
R-HSA-9013004
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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RHOA binds effectors at the ER membrane
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Kinectin, a kinesin anchor involved in kinesin mediated vesicle motility, interacts with the GTP bound (active) form of RHOA (Hotta et al. 1996, Alberts et al. 1998, Vignal et al. 2001).

The following endoplasmic reticulum proteins have been identified as putative RHOA effectors in the high throughput screen by Bagci et al. and are annotated as candidate RHOA effectors:
ATP6AP1 (Bagci et al. 2020)
BCAP31 (Bagci et al. 2020)
CCDC115 (Bagci et al. 2020)
DDRGK1 (Bagci et al. 2020)
EMC3 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
LMAN1 (Bagci et al. 2020)
MACO1 (Bagci et al. 2020)
PGRMC2 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
TEX2 (Bagci et al. 2020)
TMEM87A (Bagci et al. 2020)
VAPB (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)
Literature References
PubMed ID Title Journal Year
11689693 Kinectin is a key effector of RhoG microtubule-dependent cellular activity

Vignal, E, Blangy, A, Martin, M, Gauthier-Rouvière, C, Fort, P

Mol. Cell. Biol. 2001
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
8769096 Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

Hotta, K, Tanaka, K, Mino, A, Kohno, H, Takai, Y

Biochem. Biophys. Res. Commun. 1996
9535835 Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7

Alberts, AS, Bouquin, N, Johnston, LH, Treisman, R

J. Biol. Chem. 1998
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Orthologous Events
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RHOA binds effectors at the ER membrane (Gallus gallus)
RHOA binds effectors at the ER membrane (Mus musculus)
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RHOA binds effectors at the ER membrane (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Created
Orlic-Milacic, M  (2017-07-21)
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