In the presence of a myelin component (GMDI), such as MAG, NOGO or OMG, bound to a complex of the NOGO receptor (RTN4R, also known as NgR) and NGFR (p75NTR), binding of NGFR to ARHGDIA, a RHO-GDI, associated with RHOA:GDP, is strengthened (Yamashita and Tohyama 2003). The presence of LINGO1 in the complex of NGFR, RTN4R and MAG, NOGO or OMG is needed for NGFR-dependent activation of RHOA (Mi et al. 2004).
Thill, G, Shao, Z, Crowell, T, Allaire, N, Cate, RL, Lee, X, Pepinsky, RB, Relton, J, Sands, B, Mi, S, Ji, B, Levesque, M, Perrin, S, McCoy, JM
Yamashita, T, Tohyama, M
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