The p75NTR:NgR:MDGI binds RHOA-GDI

Stable Identifier
Reaction [binding]
Homo sapiens
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In the presence of a myelin component (GMDI), such as MAG, NOGO or OMG, bound to a complex of the NOGO receptor (RTN4R, also known as NgR) and NGFR (p75NTR), binding of NGFR to ARHGDIA, a RHO-GDI, associated with RHOA:GDP, is strengthened (Yamashita and Tohyama 2003). The presence of LINGO1 in the complex of NGFR, RTN4R and MAG, NOGO or OMG is needed for NGFR-dependent activation of RHOA (Mi et al. 2004).

Literature References
PubMed ID Title Journal Year
12692556 The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

Yamashita, T, Tohyama, M

Nat Neurosci 2003
14966521 LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Mi, S, Lee, X, Shao, Z, Thill, G, Ji, B, Relton, J, Levesque, M, Allaire, N, Perrin, S, Sands, B, Crowell, T, Cate, RL, McCoy, JM, Pepinsky, RB

Nat Neurosci 2004
Participant Of
Orthologous Events
Cross References
Target Pathogen
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