In the presence of a myelin component (GMDI), such as MAG, NOGO or OMG, bound to a complex of the NOGO receptor (RTN4R, also known as NgR) and NGFR (p75NTR), binding of NGFR to ARHGDIA, a RHO-GDI, associated with RHOA:GDP, is strengthened (Yamashita and Tohyama 2003). The presence of LINGO1 in the complex of NGFR, RTN4R and MAG, NOGO or OMG is needed for NGFR-dependent activation of RHOA (Mi et al. 2004).
Yamashita, T, Tohyama, M
Mi, S, Lee, X, Shao, Z, Thill, G, Ji, B, Relton, J, Levesque, M, Allaire, N, Perrin, S, Sands, B, Crowell, T, Cate, RL, McCoy, JM, Pepinsky, RB
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