Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K

EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K

Stable Identifier

R-HSA-9012657

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K

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Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) binds phosphorylated IRS2 associated with the phosphorylated EPOR (Bouscary et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12506011	Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation Claessens, YE, Mayeux, P, Fontenay-Roupie, M, Bouscary, D, Pene, F, Lacombe, C, Muller, O, Chrétien, S, Gisselbrecht, S	Blood	2003
11598010	Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase Kubota, Y, Kitanaka, A, Ishida, T, Kamano, H, Ohnishi, H, Waki, M, Tanaka, T, Okutani, Y	EMBO J.	2001