EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5

Stable Identifier
R-HSA-9012654
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
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STAT5 (STAT5A or STAT5B) binds the phosphorylated cytoplasmic domain of EPOR via phosphotyrosine-343 and phosphotyrosine-479 of EPOR (Chretien et al. 1996, McGraw et al. 2012, and inferred from mouse homologs). STAT5 may also bind the EPOR complex indirectly via CRKL (Ota et al. 1998).

Literature References
PubMed ID Title Journal Year
9837784 Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin

Shimamura, S, Suzu, S, Kimura, F, Nagata, N, Ota, J, Wakimoto, N, Sato, K, Motoyoshi, K, Nakamura, Y, Yamada, M

Biochem. Biophys. Res. Commun. 1998
8861946 Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation

Mayeux, P, Lacombe, C, Verdier, F, Gisselbrecht, S, Gobert, S, Varlet, P, Chrétien, S, Cartron, JP

EMBO J. 1996
22509308 Erythropoietin receptor signaling is membrane raft dependent

Clark, JA, Johnson, JO, McGraw, KL, Sokol, L, Fuhler, GM, Caceres, GC, List, AF

PLoS ONE 2012
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phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5 (Mus musculus)
Authored
May, B  (2017-06-17)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-07-17)
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