p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2

Stable Identifier
R-HSA-9012651
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
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After being phosphorylated, phospho-STAT5 (STAT5A or STAT5B) dissociates from the EPO:EPOR complex, dimerizes, and transits to the nucleus where it activates transcription of target genes (Oda et al. 1998, and inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
9657743 Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors

Oda, A, Koike, T, Druker, BJ, Sawada, K, Ozaki, K, Koizumi, K, Ikeda, Y, Handa, M, Fukada, Y, Takano, H

Blood 1998
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Inferred From
p-Stat5 dissociates from Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 (Mus musculus)
Authored
May, B  (2017-06-17)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-07-17)
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