JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2

Stable Identifier
R-HSA-9012650
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After STAT5 binds the EPO:EPOR complex, phosphorylated JAK2 and LYN phosphorylate STAT5 (STAT5A or STAT5B) (Gouilleux et al. 1995, Pallard et al. 1995, Hoefsloot et al. 1997, Miura et al. 1998, Oda et al. 1998, Okajima et al. 1998, Erickson-Miller et al. 2000, and inferred from mouse homologs). STAT5A (MGH-STAT5) is phosphorylated on tyrosine-694 (Gouilleux et al. 1995, Arcasoy et al. 1999). Activation of STAT5 appears to be impaired in myelodysplastic syndrome (Hoefsloot et al. 1997). IGF-I enhances STAT5 phosphorylation in response to EPO (Okajima et al. 1998).
Literature References
PubMed ID Title Journal Year
7744007 Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity

Wakao, H, Groner, B, Norstedt, G, Haldosen, LA, Levy, D, Dusanter-Fourt, I, Pallard, C, Gouilleux, F

EMBO J. 1995
9923445 A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation

Forget, BG, Arcasoy, MO, Harris, KW

Exp. Hematol. 1999
9722506 Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5

Matsuzawa, Y, Wakao, H, Ishikawa, J, Hashimoto, K, Matsumura, I, Yoshimura, A, Nishiura, T, Kanakura, Y, Tomiyama, Y, Yoshida, H, Okajima, Y

J. Biol. Chem. 1998
9057652 Erythropoietin-induced activation of STAT5 is impaired in the myelodysplastic syndrome

van der Plas, DC, Touw, IP, van Amelsvoort, MP, Löwenberg, B, van Lom, K, Hoogerbrugge, H, Hoefsloot, LH, Broeders, LC

Blood 1997
11007921 Signaling induced by erythropoietin and stem cell factor in UT-7/Epo cells: transient versus sustained proliferation

Erickson-Miller, CL, Pelus, LM, Lord, KA

Stem Cells 2000
9587401 Regulation of both erythroid and megakaryocytic differentiation of a human leukemia cell line, UT-7

Kirito, K, Miura, Y, Komatsu, N

Acta Haematol. 1998
9657743 Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors

Oda, A, Koike, T, Druker, BJ, Sawada, K, Ozaki, K, Koizumi, K, Ikeda, Y, Handa, M, Fukada, Y, Takano, H

Blood 1998
7608147 Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells

Groner, B, Charon, M, Gisselbrecht, S, Dusanter-Fourt, I, Pallard, C, Gouilleux, F

J. Biol. Chem. 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane]

Physical Entity
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 phosphorylates Stat5 (Mus musculus)
Authored
May, B  (2017-06-17)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-07-17)
Cite Us!