EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane]

Stable Identifier
R-HSA-9012639
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
11598010 Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

Kubota, Y, Tanaka, T, Kitanaka, A, Ohnishi, H, Okutani, Y, Waki, M, Ishida, T, Kamano, H

EMBO J. 2001
9334184 Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation

Verdier, F, Chrétien, S, Billat, C, Gisselbrecht, S, Lacombe, C, Mayeux, P

J. Biol. Chem. 1997
15149544 PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors

Schmidt, EK, Fichelson, S, Feller, SM

BMC Biol. 2004
Participants
components
Participant Of
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Inferred To
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Bos taurus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Sus scrofa)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Xenopus tropicalis)