Reactome | IL18-2(37-189) [extracellular region]

IL18-2(37-189) [extracellular region]

Stable Identifier

R-HSA-9012548

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IL18 isoform alpha

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14116-2 IL18

Gene Names

IL18, IGIF, IL1F4

Other Identifiers

1165_at

11727092_x_at

16744415

206295_3p_at

206295_PM_at

206295_at

3391256

3391257

3391258

3391266

3391267

3391268

3391269

3391270

3391271

3391273

3391274

3391275

3391277

3391278

3391279

3391284

3391285

3391286

3606

7951686

A_23_P104798

D49950_at

GE57234

GO:0001525

GO:0001819

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0006355

GO:0006954

GO:0006955

GO:0007267

GO:0008283

GO:0010628

GO:0010744

GO:0023052

GO:0030101

GO:0030155

GO:0030431

GO:0032722

GO:0032725

GO:0032729

GO:0032736

GO:0032740

GO:0032819

GO:0034105

GO:0035655

GO:0042088

GO:0042092

GO:0042104

GO:0042119

GO:0042267

GO:0042531

GO:0042632

GO:0045515

GO:0045630

GO:0045662

GO:0045944

GO:0048018

GO:0048661

GO:0048856

GO:0050729

GO:0050830

GO:0051092

GO:0051142

GO:0051897

GO:0061436

GO:0070328

GO:0098542

GO:0098772

GO:0120162

GO:0150078

GO:1901224

GO:2000556

HMNXSV003036617

ILMN_1778457

TC11002293.hg

g4504652_3p_at

g4504652_3p_x_at

This entity regulates

Positively

IL18 binds IL18R1 (Homo sapiens)

Inferred To

IL18 [extracellular region] (Bos taurus)

IL18 [extracellular region] (Canis familiaris)

IL18 [extracellular region] (Sus scrofa)

Homologues of IL18-2(37-189) [extracellular region] (Sus scrofa)

Homologues of IL18-2(37-189) [extracellular region] (Xenopus tropicalis)

Il18 [extracellular region] (Mus musculus)

Il18 [extracellular region] (Rattus norvegicus)

LOC105946938 [extracellular region] (Xenopus tropicalis)

il1b [extracellular region] (Xenopus tropicalis)

IL-18 [extracellular region] (Gallus gallus)

Cross References

OpenTargets

ENSG00000150782

ENSEMBL

ENSP00000434561, ENSP00000434161, ENST00000280357, ENSP00000280357, ENSG00000150782, ENST00000528832, ENST00000524595

HPA

ENSG00000150782-IL18

GeneCards

IL18

PRO

Q14116

Pharos - Targets

Q14116

GlyGen

Q14116

PDB

2VXT, 1J0S, 8J6K, 8SV1, 4EKX, 4R6U, 8SPB, 3F62, 4HJJ, 3WO4, 4XFU, 3WO3, 4XFT, 7AL7, 4XFS, 4EEE, 3WO2, 8URV

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48594 SPB4			0.589	2
UniProt:Q13478 IL18R1	1	IL18R1 [plasma membrane] (R-HSA-197600)	0.558	2
UniProt:Q9IW12 Q9IW12			0.558	2
UniProt:Q15847 ADIRF	1	ADIRF [nucleoplasm] (R-HSA-8936822)	0.556	3
UniProt:P13385 TDGF1	1	N-aspartyl-glycosylphosphatidylinositolethanolamine-TDGF1(31-188) [plasma membrane] (R-HSA-452300)	0.527	2
UniProt:Q9BV97 ZNF747	1	ZNF747 [nucleoplasm] (R-HSA-2586596)	0.527	2
UniProt:Q9Y3C0 WASC3			0.527	2

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