Estrogen-responsive CHD1 gene transcription

Stable Identifier
Reaction [omitted]
Homo sapiens
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CHD1 is an ATP-dependent chromatin remodelling factor that is a component of the SAGA complex (Sims et al, 2007; reviewed in Marfella and Imbalzano, 2007). CHD1 expression has been shown to be responsive to estrogen stimulation, and negatively regulated by direct binding of mIR-26A and mIR-26B to the 3' UTR. MYC- and estrogen-dependent down-regulation of mIR-26 expression abrogates the repressive effect on CHD1 expression and promotes the estrogen-responsive proliferative effect (Tan et al, 2014).

Literature References
PubMed ID Title Journal Year
24735615 Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2

Li, G, Kong, X, Tan, S, Zhu, T, Ding, K, Li, R, Lobie, PE, Qian, P, Zhang, W

Breast Cancer Res. 2014
18042460 Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing

Lewis, BA, Chen, CF, Reinberg, D, Millhouse, S, Sims, RJ, Manley, JL, Tempst, P, Erdjument-Bromage, H

Mol. Cell 2007
17350655 The Chd family of chromatin remodelers

Imbalzano, AN, Marfella, CG

Mutat. Res. 2007
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