Reactome | KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers

KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers

Stable Identifier

R-HSA-9011949

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers

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KDM4B (also known as JMJD2B) is an H3 K9 demethylase that is recruited to estrogen-responsive enhancers through interaction with ESR1 (Kawazu et al, 2011; Gaughan et al, 2013). KDM4B promotes target gene activation in the presence of estrogen by removing the repressive H3K9 methylation mark, and KDM4B has been shown to interact with the SWI/SNF-B complex component SMARCA4 and to promote recruitment of RNA polymerase II (Kawazu et al, 2011; Gaughan et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
23723241	KDM4B is a master regulator of the estrogen receptor signalling cascade Gaughan, L, Stockley, J, Coffey, K, O'Neill, D, Jones, DL, Wade, M, Wright, J, Moore, M, Tse, S, Rogerson, L, Robson, CN	Nucleic Acids Res.	2013
21445275	Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development Kawazu, M, Saso, K, Tong, KI, McQuire, T, Goto, K, Son, DO, Wakeham, A, Miyagishi, M, Mak, TW, Okada, H	PLoS ONE	2011