KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

KDM4B (also known as JMJD2B) is an H3 K9 demethylase that is recruited to estrogen-responsive enhancers through interaction with ESR1 (Kawazu et al, 2011; Gaughan et al, 2013). KDM4B promotes target gene activation in the presence of estrogen by removing the repressive H3K9 methylation mark, and KDM4B has been shown to interact with the SWI/SNF-B complex component SMARCA4 and to promote recruitment of RNA polymerase II (Kawazu et al, 2011; Gaughan et al, 2013).

Literature References
PubMed ID Title Journal Year
23723241 KDM4B is a master regulator of the estrogen receptor signalling cascade

Wade, M, O'Neill, D, Gaughan, L, Stockley, J, Tse, S, Robson, CN, Moore, M, Coffey, K, Rogerson, L, Jones, DL, Wright, J

Nucleic Acids Res. 2013
21445275 Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development

Okada, H, McQuire, T, Goto, K, Mak, TW, Miyagishi, M, Son, DO, Saso, K, Kawazu, M, Wakeham, A, Tong, KI

PLoS ONE 2011
Catalyst Activity

histone H3-methyl-lysine-9 demethylase activity of KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm]

Orthologous Events
Cite Us!