Reactome | IL9R binds JAK1

IL9R binds JAK1

Stable Identifier

R-HSA-9011748

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Interleukin-9 receptor (IL9R) binds Tyrosine-protein kinase JAK1 (JAK1); this association is believed to be constitutive (Demoulin et al. 1996, Zhu et al 1997). The association is ascribed to a 98-residue juxta-membrane region within the BOX1 motif of the receptor that contains a Pro-X-Pro sequence preceded by a cluster of hydrophobic residues, a consensus sequence shared by many other cytokine receptors e.g. IL4R, IL7R, IL3R (Murakami et al. 1991, Zhu et al 1997).

Literature References

PubMed ID	Title	Journal	Year
8756628	A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Uyttenhove, C, Demoulin, JB, Van Snick, J, Van Roost, E, Donckers, D, DeLestré, B, Renauld, JC	Mol. Cell. Biol.	1996