Interleukin-9 receptor (IL9R) binds Tyrosine-protein kinase JAK1 (JAK1); this association is believed to be constitutive (Demoulin et al. 1996, Zhu et al 1997). The association is ascribed to a 98-residue juxta-membrane region within the BOX1 motif of the receptor that contains a Pro-X-Pro sequence preceded by a cluster of hydrophobic residues, a consensus sequence shared by many other cytokine receptors e.g. IL4R, IL7R, IL3R (Murakami et al. 1991, Zhu et al 1997).
Uyttenhove, C, Demoulin, JB, Van Snick, J, Van Roost, E, Donckers, D, DeLestré, B, Renauld, JC
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