ROBO3.1 binds DCC

Stable Identifier
R-HSA-9011224
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on studies in mice and biochemical studies with human DCC and mouse Robo3.1, ROBO3.1 (also known as ROBO3A.1) can bind to DCC both in the presence and absence of netrin-1 (NTN1). The two proteins interact via their intracellular domains through the P3 domain of DCC and the CC2 and CC3 motifs of ROBO3. Binding of ROBO3.1 to DCC apparently contributes to NTN1-mediated attraction of commissural axons to the midline (Zelina et al. 2014).

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