ROBO3.1 expression is stimulated by LHX2,(LHX9)

Stable Identifier
R-HSA-9011143
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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ROBO3.1 expression is stimulated by LHX2,(LHX9)
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Based on studies in mice, expression of the ROBO3.1 isoform from the ROBO3 gene is directly stimulated by LHX2 and possibly LHX9. LHX2/9-mediated regulation of ROBO3.1 levels is involved in midline crossing by commissural relay neurons of the dorsal spinal cord (Wilson et al. 2008). ROBO3.1 levels, however, seem to be unaffected by LHX2 in thalamocortical neurons (Marcos-Mondejar et al. 2012).
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Output
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as an event of
This event is regulated
Positively by
Regulator
LHX2,(LHX9):ROBO3 gene [nucleoplasm] (Homo sapiens)
Active Unit
LHX2,(LHX9) [nucleoplasm]
Inferred From
Robo3.1 expression is stimulated by Lhx2,(Lhx9) (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-29)
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