SLITs bind keratan sulfate

Stable Identifier
R-HSA-9010815
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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SLITs bind keratan sulfate
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SLIT2 is expressed by corneal epithelial cells and able to bind to keratan sulfate, which is part of the corneal stroma extracellular matrix. This interaction may influence corneal nerve growth cone penetration. SLIT3 may also interact with keratan sulfate, as well as ROBO receptors ROBO1 and ROBO2 (Conrad et al. 2010).
Literature References
PubMed ID Title Journal Year
20375348 Proteomic analysis of potential keratan sulfate, chondroitin sulfate A, and hyaluronic acid molecular interactions

Zhang, Y, Conrad, AH, Conrad, GW, Tasheva, ES

Invest. Ophthalmol. Vis. Sci. 2010
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Orthologous Events
SLITs bind keratan sulfate (Bos taurus)
SLITs bind keratan sulfate (Caenorhabditis elegans)
SLITs bind keratan sulfate (Canis familiaris)
SLITs bind keratan sulfate (Drosophila melanogaster)
SLITs bind keratan sulfate (Gallus gallus)
SLITs bind keratan sulfate (Mus musculus)
SLITs bind keratan sulfate (Sus scrofa)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-28)
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